Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling.

@article{Zhao2015ElevatedPC,
  title={Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling.},
  author={Yingzi Zhao and Sheila Flavahan and Susan W S Leung and Aimin Xu and Paul Michel Vanhoutte and Nicholas A Flavahan},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2015},
  volume={308 4},
  pages={H358-63}
}
Experiments were performed to determine whether or not acute exposure to elevated pressure would disrupt endothelium-dependent dilatation by increasing local angiotensin II (ANG II) signaling. Vasomotor responses of mouse-isolated carotid arteries were analyzed in a pressure myograph at a control transmural pressure (PTM) of 80 mmHg. Acetylcholine-induced dilatation was reduced by endothelial denudation or by inhibition of nitric oxide synthase (NG-nitro-L-arginine methyl ester, 100 μM… CONTINUE READING

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