Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?

@article{Desai2003ElevatedPV,
  title={Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?},
  author={Niraj M. Desai and John Alan Goss and Shaoping Deng and Bryan A. Wolf and Eileen Markmann and Maral Palanjian and Angela P Shock and S A San Feliciano and Francis Charles Brunicardi and Clyde F. Barker and Hussien Ali Naji and James F. Markmann},
  journal={Transplantation},
  year={2003},
  volume={76 11},
  pages={
          1623-5
        }
}
The recent success of islet transplantation using the Edmonton protocol involved the use of sirolimus, tacrolimus, and daclizumab for immunosuppression. Islets were infused into the portal circulation after transhepatic access. This protocol provided a unique opportunity to measure sirolimus and tacrolimus levels from the portal vein and compare them to systemic venous levels. A total of 11 portal venous samples with a corresponding peripheral venous sample were obtained from patients… CONTINUE READING
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