Elevated platelet-associated IgG in the thrombocytopenia of septicemia.

  title={Elevated platelet-associated IgG in the thrombocytopenia of septicemia.},
  author={John G. Kelton and P B Neame and Jack Gauldie and Jack Hirsh},
  journal={The New England journal of medicine},
  volume={300 14},
The mechanism of thrombocytopenia, a frequent complication of septicemia, is obscure, but indirect evidence suggests that the immune system may be involved. To investigate this possibility, we quantitated platelet-associated IgG on platelets obtained from 44 patients during 46 episodes of septicemia. Thrombocytopenia occurred in 21 of 46 episodes (46 per cent). Platelet-associated IgG was elevated in eight of 11 episodes of gram-negative septicemia and thrombocytopenia (47.3 +/- 11.7 fg of IgG… CONTINUE READING

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