Elevated plasminogen activator inhibitor 1 in sleep apnea and its relation to the metabolic syndrome: an investigation in 2 different study samples.

@article{Knel2007ElevatedPA,
  title={Elevated plasminogen activator inhibitor 1 in sleep apnea and its relation to the metabolic syndrome: an investigation in 2 different study samples.},
  author={Roland von K{\"a}nel and Jos{\'e} S. Loredo and Sonia Ancoli-Israel and Paul J. Mills and Joel E. Dimsdale},
  journal={Metabolism: clinical and experimental},
  year={2007},
  volume={56 7},
  pages={969-76}
}
Increased circulating levels of plasminogen activator inhibitor 1 (PAI-1) have been associated with atherothrombosis. Plasminogen activator inhibitor 1 levels are elevated in obstructive sleep apnea (OSA) and in the metabolic syndrome, both of which confer excess coronary risk. We investigated whether apnea-hypopnea index (AHI) and the metabolic syndrome would interact in determining plasma concentration of PAI-1. Full-night polysomnography was performed in 2 different groups consisting of a… CONTINUE READING

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