Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications.

@article{Lopansri2006ElevatedPP,
  title={Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications.},
  author={Bert K Lopansri and Nicholas M Anstey and Gregory J. Stoddard and Esther D. Mwaikambo and Craig Steven Boutlis and Emiliana Tjitra and Helena Maniboey and Maurine R. Hobbs and Marc C. Levesque and J Brice Weinberg and Donald L. Granger},
  journal={Infection and immunity},
  year={2006},
  volume={74 6},
  pages={3355-9}
}
Cerebral malaria is associated with decreased production of nitric oxide and decreased levels of its precursor, l-arginine. Abnormal amino acid metabolism may thus be an important factor in malaria pathogenesis. We sought to determine if other amino acid abnormalities are associated with disease severity in falciparum malaria. Subjects were enrolled in Dar es Salaam, Tanzania (children) (n = 126), and Papua, Indonesia (adults) (n = 156), in two separate studies. Plasma samples were collected… CONTINUE READING
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