Elevated plasma phenylalanine concentrations may adversely affect bone status of phenylketonuric mice

@article{Yannicelli2002ElevatedPP,
  title={Elevated plasma phenylalanine concentrations may adversely affect bone status of phenylketonuric mice},
  author={Steven Yannicelli and Denis M. Medeiros},
  journal={Journal of Inherited Metabolic Disease},
  year={2002},
  volume={25},
  pages={347-361}
}
Children with phenylketonuric (PKU) are at risk for fractures. This study used a PKU murine model (PAH enu-2 ) to evaluate effects of moderate dietary protein restriction and elevated plasma phenylalanine concentration impact upon bone status. Fifty-four male weanling PKU and control mice were assigned to either an elemental phenylalanine (Phe)-restricted diet (treated) or Phe-unrestricted diet (untreated) with low or normal protein levels for 56 days. Untreated mice and control mice received… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Diet therapy for phenylketonuria: new challenges

  • K Michals
  • Top Clin Nutr
  • 1987
Highly Influential
5 Excerpts

Biomechanics of bone

  • TA Einhorn
  • In Bilezikian JP, Raisz LB, Rodan GA, eds…
  • 1996
Highly Influential
3 Excerpts

Bone mineral density in patients with phenylketonuria

  • J Zeman, M Bayer, J Stephan
  • Acta Paediatr
  • 1999
1 Excerpt

Development and application of a synthetic peptide based osteocalcin radioimmunoassay for the measurement of bone formation in mouse serum

  • AK Srivastava, G Castillo, MJ Grace, D Baylink
  • J Bone Miner Res
  • 1999
1 Excerpt

Similar Papers

Loading similar papers…