Elevated plasma levels of tissue inhibitors of metalloproteinase-1 and their overexpression in muscle in human and mouse muscular dystrophy

@article{Sun2010ElevatedPL,
  title={Elevated plasma levels of tissue inhibitors of metalloproteinase-1 and their overexpression in muscle in human and mouse muscular dystrophy},
  author={Guilian Sun and Kazuhiro Haginoya and Yoko Chiba and Mitsugu Uematsu and Shigeru Tsuchiya},
  journal={Journal of the Neurological Sciences},
  year={2010},
  volume={297},
  pages={19-28}
}
To investigate the role of tissue inhibitors of metalloproteinases (TIMPs) in muscular dystrophy, we examined the expression of TIMP-1 using plasma and biopsied muscle from patients with various muscular dystrophies by ELISA, immunohistochemistry, and Western blot analysis. TIMP-1 immunolocalization was also studied in mouse models of muscular dystrophy. Plasma TIMP-1 was elevated and correlated with TGF-β1 in Duchenne muscular dystrophy (DMD) and congenital muscular dystrophy (CMD), but not in… CONTINUE READING

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