Elevated plasma histamine concentrations in surgery: Causes and clinical significance

@article{Lorenz1974ElevatedPH,
  title={Elevated plasma histamine concentrations in surgery: Causes and clinical significance},
  author={Wilfried Lorenz and W. Seidel and Alfred W Doenicke and Robert Tauber and H. -J. Reimann and Ralph Uhlig and Gideon Mann and Petra Dormann and Anton Schmal and Gerhart H{\"a}fner and Horst Hamelmann},
  journal={Klinische Wochenschrift},
  year={1974},
  volume={52},
  pages={419-425}
}
Histamine concentrations in plasma, whole blood and various tissues of human subjects, monkeys, pigs and dogs were determined by fluorometric methods before, during and after surgical operations. Following intraabdominal surgery in 6 of 22 patients elevated plasma histamine levels were found several hours after the end of operation. Some of the causes of histamine release in surgery were found to be premedication by atropine, intravenously administered anaesthetics, infusion of plasma… CONTINUE READING