Elevated plasma ghrelin levels in Prader–Willi syndrome

@article{Cummings2002ElevatedPG,
  title={Elevated plasma ghrelin levels in Prader–Willi syndrome},
  author={D. Cummings and Karine Cl{\'e}ment and J. Purnell and C. Vaisse and Karen E. Foster and R. S. Frayo and M. Schwartz and A. Basdevant and D. S. Weigle},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={643-644}
}

Figures and Topics from this paper

The roles of the preproghrelin-derived peptides - ghrelin, desacyl ghrelin and obestatin - in prostate cancer
TLDR
A chronology of key events and figures leading to the creation of the Declaration of Independence and its publication as well as some of the statements of origin and subsequent publications are presented. Expand
Neonatal Maternal Deprivation Response and Developmental Changes in Gene Expression Revealed by Hypothalamic Gene Expression Profiling in Mice
TLDR
Genes that are affected by adult starvation showed no expression change in the hypothalamus of 5 day-old pups after 6 hours of maternal deprivation, and expression levels of Nanos2 and Pdk4 were increased, and those of Pgpep1, Ndp, Brms1l, Mett10d, and Snx1 were decreased after neonatal deprivation. Expand
Pediatric Endocrine Disorders of Energy Balance
  • R. Lustig
  • Medicine
  • Reviews in Endocrine and Metabolic Disorders
  • 2005
TLDR
This review will elucidate the genetic/endocrine disorders that promote weight gain and obesity in children that impact at various points on the negative feedback pathway of energy balance. Expand
[Ghrelin deficiency in patients with type 2 diabetes: the relationships with obesity, adipose tissue dysfunction and glucose variability].
TLDR
Ghrelin levels in patients with diabetes were decreased significantly as compared to control, and the 24-hour and nocturnal GV parameters were derived from continuous glucose monitoring. Expand
Hyperghrelinemia in Prader‐Willi syndrome begins in early infancy long before the onset of hyperphagia
TLDR
It seems unlikely that high ghrelin levels are directly responsible for the switch to the hyperphagic nutritional phases in PWS, especially during the early phase of poor appetite and feeding. Expand
The Hunger Genes: Pathways to Obesity
TLDR
A more detailed mechanistic understanding of the molecular, physiological, and behavioral pathways involved in the development of obesity in susceptible individuals is critical for identifying effective mechanism-based preventative and therapeutic interventions. Expand
Ghrelin in obesity and endocrine diseases
TLDR
Plasma ghrelin levels are dependent on body mass index as well as food intake patterns, and may have a role in the weight-reducing effect of bariatric surgery; however, this is a much debated issue. Expand
Ghrelin, obesity and type 2 diabetes : genetic, metabolic and epidemiological studies
TLDR
The results suggest that two variations in the ghrelin receptor gene might be associated with glucose and lipid metabolism but not with IGF-1 levels, and indicate that plasma gh Relin levels are influenced by acquired obesity rather than genetic determinants. Expand
Exendin-4 Potently Decreases Ghrelin Levels in Fasting Rats
TLDR
The decrease in ghrelin levels induced by Ex-4 may explain the reduced food intake in fasted rats, justifying the more potent anorexigenic effects of Ex- 4 when compared with GLP-1. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 19 REFERENCES
Human plasma ghrelin levels after dietinduced weight loss and gastric bypass surgery
  • New Engl . J . Med .
  • 2002
Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
TLDR
The increase in the plasma ghrelin level with diet-induced weight loss is consistent with the hypothesis that gh Relin has a role in the long-term regulation of body weight. Expand
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.
TLDR
The hypothesis that ghrelin plays a physiological role in meal initiation in humans is supported by the clear preprandials rise and postprandial fall in plasma ghrelIn levels. Expand
A role for ghrelin in the central regulation of feeding
TLDR
It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone. Expand
Endocrine dysfunction in Prader-Willi syndrome: a review with special reference to GH.
TLDR
Prader-Willi syndrome is a disabling condition associated with GH deficiency and hypogonadism, and more active treatment of these endocrine disorders is likely to benefit affected individuals. Expand
Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes.
The chromosomal region, 15q11-q13, involved in Prader-Willi and Angelman syndromes (PWS and AS) represents a paradigm for understanding the relationships between genome structure, epigenetics,Expand
Ghrelin causes hyperphagia and obesity in rats.
TLDR
Evidence is provided that ghrelin is important in long-term control of food intake and body weight and that circulating gh Relin at fasting concentrations may stimulate food intake. Expand
Ghrelin enhances appetite and increases food intake in humans.
TLDR
Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man and is a potentially important new regulator of the complex systems controlling food intake and body weight. Expand
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin.
TLDR
Ghrelin, which is negatively regulated by leptin and IL-1 beta, is secreted by the stomach and increases arcuate NPY expression, which in turn acts through Y(1) receptors to increase food intake and decrease energy expenditure. Expand
Ghrelin: An orexigenic and somatotrophic signal from the stomach
  • A. Inui
  • Chemistry, Medicine
  • Nature Reviews Neuroscience
  • 2001
TLDR
The study of ghrelin has extended the understanding of how growth is controlled, and has shown that the stomach is an important component of this system. Expand
...
1
2
...