Elevated plasma-free cortisol concentrations and ratios are associated with increased mortality even in the presence of statin therapy in patients with severe sepsis.

@article{Venkatesh2015ElevatedPC,
  title={Elevated plasma-free cortisol concentrations and ratios are associated with increased mortality even in the presence of statin therapy in patients with severe sepsis.},
  author={Balasubramanian Venkatesh and Lee Imeson and Peter Kruger and Jeremy Cohen and Mark Jones and Rinaldo Bellomo},
  journal={Critical care medicine},
  year={2015},
  volume={43 3},
  pages={630-5}
}
BACKGROUND Dissociation between plasma-free cortisol and total cortisol profiles exists in critical illness. Data on plasma-free cortisol are based on either calculated values or immunoassay-based measurements. Both have significant limitations. Statins have been advocated as a therapy in sepsis. Whether they impact on plasma cortisol through inhibition of… CONTINUE READING