Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel.

@article{Ang2008ElevatedPF,
  title={Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel.},
  author={Lawrence Ang and Vachaspathi Palakodeti and Ahmer Khalid and Sotirios Tsimikas and Zaheib Idrees and Phillip Tran and Paul C Clopton and Nayab Zafar and Guilherme Bromberg-Marin and Shahin Keramati and Ehtisham Mahmud},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={52 13},
  pages={1052-9}
}
OBJECTIVES The goal of this study was to identify factors associated with lower platelet inhibition (PI) with clopidogrel in subjects with cardiovascular disease (CVD). BACKGROUND A heterogeneous platelet reactivity response to clopidogrel exists, and the clinical or biochemical predictors of suboptimal PI with clopidogrel remain unclear. METHODS This study prospectively enrolled subjects with CVD requiring treatment with clopidogrel (75 mg daily for > or =7 days or 600-mg bolus > or =24 h… CONTINUE READING

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