Elevated plasma and cerebrospinal fluid interleukin-1 beta and tumor necrosis factor-alpha concentration and combined outcome of death or abnormal neuroimaging in preterm neonates with early-onset clinical sepsis

@article{Basu2015ElevatedPA,
  title={Elevated plasma and cerebrospinal fluid interleukin-1 beta and tumor necrosis factor-alpha concentration and combined outcome of death or abnormal neuroimaging in preterm neonates with early-onset clinical sepsis},
  author={Sriparna Basu and Priya Agarwal and Shampa Anupurba and Ram Chandra Shukla and Abhay Kumar},
  journal={Journal of Perinatology},
  year={2015},
  volume={35},
  pages={855-861}
}
Objective:Prematurity and sepsis are the major contributors of neonatal mortality and neurodevelopmental sequelae. The present study was conducted to measure the plasma and cerebrospinal fluid (CSF) concentration of interleukin (IL)-1β and tumor necrotic factor (TNF)-α in preterm neonates with early-onset clinical sepsis (EOCS), and to find out their association with combined outcome of death or abnormal neuroimaging.STUDY DESIGN:Thirty-two preterm (⩽34 weeks) neonates with EOCS and 32… CONTINUE READING