Elevated plasma F2-isoprostanes in patients on long-term hemodialysis.

  title={Elevated plasma F2-isoprostanes in patients on long-term hemodialysis.},
  author={Garry J Handelman and Mary F. Walter and Rohini Adhikarla and Jorge Luiz Gross and Gerard E. Dallal and Nathan W. Levin and Jeffrey B Blumberg},
  journal={Kidney international},
  volume={59 5},
BACKGROUND End-stage renal disease (ESRD) patients on long-term hemodialysis (HD) may be under increased oxidative stress, caused by either HD or renal failure. Plasma F2-isoprostanes have been established as an important indicator of in vivo oxidative stress. METHODS Plasma esterified F2-isoprostanes were measured in 25 HD patients and 23 controls with normal renal function, employing gas chromatography-mass spectrometry with negative chemical ionization (GC-MS-NCI). C-reactive protein (CRP… CONTINUE READING


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