Elevated phenotypic switching and drug resistance of Candida albicans from human immunodeficiency virus-positive individuals prior to first thrush episode.

@article{Vargas2000ElevatedPS,
  title={Elevated phenotypic switching and drug resistance of Candida albicans from human immunodeficiency virus-positive individuals prior to first thrush episode.},
  author={Kaaren G. Vargas and Shawn A. Messer and Michael A. Pfaller and Shawn R. Lockhart and Jack T. Stapleton and John Hellstein and David R Soll},
  journal={Journal of clinical microbiology},
  year={2000},
  volume={38 10},
  pages={3595-607}
}
Strains of Candida albicans obtained from human immunodeficiency virus (HIV)-positive individuals prior to their first episode of oral thrush were already in a high-frequency mode of switching and were far more resistant to a number of antifungal drugs than commensal isolates from healthy individuals. Switching in these isolates also had profound effects both on susceptibility to antifungal drugs and on the levels of secreted proteinase activity. These results suggest that commensal strains… CONTINUE READING
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