Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos.

@article{Bain2013ElevatedPI,
  title={Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos.},
  author={Nathan T. Bain and Pavneesh Madan and Dean Harvey Betts},
  journal={Molecular reproduction and development},
  year={2013},
  volume={80 1},
  pages={22-34}
}
The in vitro production of mammalian embryos suffers from low efficiency, with 50-70% of all fertilized oocytes failing to develop to the blastocyst stage. This high rate of developmental failure is due, in part, to the effects of oxidative stress generated by reactive oxygen species (ROS). The p66Shc adaptor protein controls oxidative stress response by regulating intracellular ROS levels through multiple pathways, including mitochondrial ROS generation and the repression of antioxidants. This… CONTINUE READING