Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

@article{Hayes2013ElevatedOD,
  title={Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites},
  author={Candace S. Hayes and Karen DeFeo-Mattox and Patrick M Woster and Susan K. Gilmour},
  journal={Amino Acids},
  year={2013},
  volume={46},
  pages={543-552}
}
Elevated expression of ornithine decarboxylase (ODC), the regulatory enzyme in polyamine biosynthesis, targeted to the epidermis is sufficient to promote skin tumor development following a single subthreshold dose of dimethylbenz(a)anthracene (DMBA). Since skin tumor promotion involves recruitment of hair follicle bulge stem cells harboring genetic lesions… CONTINUE READING

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