Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts.

@article{Gardner2016ElevatedNS,
  title={Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts.},
  author={Nicole M Gardner and Ronald T. Riley and Jency L. Showker and Kenneth Voss and Andrew J. Sachs and Joyce R Maddox and Janee B Gelineau-van Waes},
  journal={Toxicology and applied pharmacology},
  year={2016},
  volume={298},
  pages={56-65}
}
Fumonisin B1 (FB1) is a mycotoxin produced by a common fungal contaminant of corn. Administration of FB1 to pregnant LM/Bc mice induces exencephaly in embryos, and ingestion of FB1-contaminated food during early pregnancy is associated with increased risk for neural tube defects (NTDs) in humans. FB1 inhibits ceramide synthase enzymes in sphingolipid… CONTINUE READING