Elevated nuclear YB1 expression is associated with poor survival of patients with early breast cancer.

@article{Maciejczyk2012ElevatedNY,
  title={Elevated nuclear YB1 expression is associated with poor survival of patients with early breast cancer.},
  author={Adam Maciejczyk and Jolanta K Szelachowska and Marcin Ekiert and Rafał Matkowski and Agnieszka Hałoń and Hermann Lage and Paweł Surowiak},
  journal={Anticancer research},
  year={2012},
  volume={32 8},
  pages={3177-84}
}
BACKGROUND Y-Box-Binding (YB1) protein represents a multifunctional protein, which plays a significant role in processes of proliferation, apoptosis and control of tumour cell response to toxic agents, including chemotherapy. The present study aimed at evaluating the prognostic significance of YB1 expression in breast cancer. MATERIALS AND METHODS We analyzed nuclear and cytoplasmic expression of YB1 in 101 patients with stage II breast cancer, with 17 years of follow-up. Immunohistochemical… CONTINUE READING