Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy.

@article{Weinblatt1989ElevatedMC,
  title={Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy.},
  author={Michael E. Weinblatt and Patricia Fraser},
  journal={Arthritis and rheumatism},
  year={1989},
  volume={32 12},
  pages={1592-6}
}
Retrospective analysis of 23 rheumatoid arthritis patients receiving low-dose methotrexate (MTX) demonstrated an association between the mean corpuscular volume (MCV) and hematologic toxicity. All 6 patients who developed hematologic toxicity were folate deficient, and 4 of 6 had marked macrocytosis. Furthermore, the mean MCV of the patients who developed toxicity was significantly higher than that of the controls without toxicity (P less than 0.02). This difference in MCV was associated with… CONTINUE READING