Elevated mean arterial pressure in the ovariectomized rat was normalized by ET(A) receptor antagonist therapy: absence of cardiac hypertrophy and fibrosis.

@article{Mercier2002ElevatedMA,
  title={Elevated mean arterial pressure in the ovariectomized rat was normalized by ET(A) receptor antagonist therapy: absence of cardiac hypertrophy and fibrosis.},
  author={Isabelle K Mercier and Mylan Pham-Dang and Robert Cl{\'e}ment and Hugues Gosselin and Federico Colombo and Jean Lucien Rouleau and Angelino Calderone},
  journal={British journal of pharmacology},
  year={2002},
  volume={136 5},
  pages={685-92}
}
1. The influence of menopause on ventricular function and remodelling remains undefined. The following study examined the effect of ovariectomy on ventricular contractility, cardiac hypertrophy and extracellular matrix protein expression. 2. Elevated circulating levels of the vasoconstrictor endothelin-1 have been reported in post-menopausal women. Moreover, endothelin-1 has been shown to influence blood pressure, ventricular function and cardiac remodelling. In this regard, the potential… CONTINUE READING

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