Elevated macrophage migration inhibitory factor (MIF) levels in the urine of patients with focal glomerular sclerosis.

@article{Matsumoto2005ElevatedMM,
  title={Elevated macrophage migration inhibitory factor (MIF) levels in the urine of patients with focal glomerular sclerosis.},
  author={Koichi Matsumoto and Nobuyuki Maruyama and Takayuki Maruyama and Yasuyuki Ohnishi and Satoko Nonaka and Ayako Inoshita and Kazuhiro Ito and Shinichi Kitajima and Mitsuhiko Abe and Atsushi Satomura and Teizo Fujita},
  journal={Clinical and experimental immunology},
  year={2005},
  volume={139 2},
  pages={338-47}
}
The pathogenesis of focal glomerular sclerosis (FGS) is poorly understood. Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine released from T cells and macrophages, and is a key molecule in inflammation. To examine further the possible role of MIF in FGS, we measured MIF levels in the urine. The purpose of the present study was to evaluate the involvement of MIF in FGS. Urine samples were obtained from 20 FGS patients. The disease controls included 40 patients… CONTINUE READING

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