Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer's Disease Subjects.

@article{Yoshino2016ElevatedME,
  title={Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer's Disease Subjects.},
  author={Yuta Yoshino and Takaaki Mori and Taku Yoshida and Kiyohiro Yamazaki and Yuki Ozaki and Tomoko Sao and Yu Funahashi and Jun-Ichi Iga and Shu-Ichi Ueno},
  journal={Journal of Alzheimer's disease : JAD},
  year={2016},
  volume={54 4},
  pages={
          1349-1357
        }
}
Despite the continuing debate about the amyloid hypothesis in Alzheimer's disease (AD), the precise pathogenesis is still unclear. Mixed pathology is common and multiple different protein aggregates are seen in human postmortem brains. Aggregates consisting of the alpha-synuclein protein encoded by the Synuclein Alpha gene (SCNA) are common in both dementia with Lewy bodies and AD. We examined SNCA mRNA expression and methylation rates of the CpG island at intron 1 of SNCA in peripheral… CONTINUE READING
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DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies.

  • Psychiatry and clinical neurosciences
  • 2017
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