Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine.

@article{Bckman2003ElevatedLA,
  title={Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine.},
  author={Cristina M. B{\"a}ckman and Zhi Bing You and Thomas Perlmann and Barry J. Hoffer},
  journal={Behavioural brain research},
  year={2003},
  volume={143 1},
  pages={95-100}
}
Gene targeting experiments, in which both alleles of the Nurr1 gene were deleted, have shown that this molecule plays an essential role in the development of midbrain dopaminergic neurons, as shown by the loss of dopaminergic markers and the neurotransmitter dopamine (DA) in the ventral mesencephalon of Nurr1 null mutant mice. Nurr1-deficient mice die within a few hours of birth. Herein, we investigated whether adult mice (12-15-month-old), heterozygous for the Nurr1 mutation (Nurr1(+/-)), show… CONTINUE READING

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