Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle.

@article{Rajah1999ElevatedLO,
  title={Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle.},
  author={Roopmathy Rajah and R V Nachajon and M H Collins and Hakon Hakonarson and Michael M. Grunstein and Pinchas Cohen},
  journal={American journal of respiratory cell and molecular biology},
  year={1999},
  volume={20 2},
  pages={199-208}
}
We have previously demonstrated that the asthma-associated proinflammatory eicosanoid leukotriene D4 (LTD4) is co-mitogenic with insulin-like growth factors (IGFs) in airway smooth-muscle (ASM) cells in vitro. This synergistic effect of LTD4 and IGF on ASM cell growth involves proteolysis of ASM-produced IGF binding proteins (IGFBPs), which are cell growth-inhibitory proteins. We also identified this IGFBP protease to be the matrix metalloproteinase-1 (MMP-1), and showed that this enzyme had a… CONTINUE READING
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