Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.

@article{Giri1994ElevatedLO,
  title={Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.},
  author={Judith G. Giri and Jay Wells and Steven K. Dower and Charles E McCall and Renaldo Guzm{\'a}n and Jonathan Slack and Timothy A. Bird and K D Shanebeck and Kenneth H. Grabstein and J. E. Sims},
  journal={Journal of immunology},
  year={1994},
  volume={153 12},
  pages={5802-9}
}
Two types of cellular IL-1Rs have been characterized and cloned from both human and murine sources. The type II IL-1R has a very short cytoplasmic domain and does not seem to participate in IL-1 signaling. We demonstrate that type II IL-1Rs are released from the surface of neutrophils in response to treatment with TNF or endotoxin. In addition, serum from… CONTINUE READING