Elevated levels of platelet- and red cell-derived extracellular vesicles in transfusion-dependent β-thalassemia/HbE patients with pulmonary arterial hypertension

@article{Manakeng2018ElevatedLO,
  title={Elevated levels of platelet- and red cell-derived extracellular vesicles in transfusion-dependent β-thalassemia/HbE patients with pulmonary arterial hypertension},
  author={Kanchana Manakeng and Phongsak Prasertphol and Kunwadee Phongpao and Suporn Chuncharunee and Dalina I. Tanyong and Suchin Worawichawong and Saovaros Svasti and Pornthip Chaichompoo},
  journal={Annals of Hematology},
  year={2018},
  volume={98},
  pages={281-288}
}
Pulmonary arterial hypertension (PAH) is a serious complication in β-thalassemia. The mechanism of PAH development is believed to be through chronic platelet activation and red cell (RBC) membrane abnormality contributing to a hypercoagulable state and thrombosis, which consequently leads to the development of PAH. Extracellular vesicles (EVs) shed from the plasma membrane of platelets and RBCs are found to be associated with thrombotic risk. This study aimed to investigate the involvement of… CONTINUE READING
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