Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury.

@article{Prabhakaran2003ElevatedLO,
  title={Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury.},
  author={P. Joy Prabhakaran and Lorraine B. Ware and Kimberly E. White and Michael T Cross and Michael A. Matthay and Mitchell A. Olman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 1},
  pages={
          L20-8
        }
}
The alveolar fibrinolytic system is altered in acute lung injury (ALI). Levels of the fibrinolytic protease inhibitor, plasminogen activator inhibitor-1 (PAI-1), are too low in bronchoalveolar lavage to address its prognostic significance. This study was performed to assess whether PAI-1 antigen in undiluted pulmonary edema fluid levels can identify patients with ALI and predict their outcome. PAI-1 antigen levels in both plasma and edema fluid were higher in ALI compared with hydrostatic edema… CONTINUE READING

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