Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.

@article{Hogan2008ElevatedLO,
  title={Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.},
  author={Carol Hogan and Caroline Hutchison and Lynnette Marcar and Diane Milne and Mark Saville and John Goodlad and Neil M. Kernohan and David C Meek},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 26},
  pages={18012-23}
}
Mutation of the p53 gene is a common event during tumor pathogenesis. Other mechanisms, such as mdm2 amplification, provide alternative routes through which dysfunction of the p53 pathway is promoted. Here, we address the hypothesis that elevated expression of pim oncogenes might suppress p53 by regulating Mdm2. At a physiological level, we show that endogenous Pim-1 and Pim-2 interact with endogenous Mdm2. Additionally, the Pim kinases phosphorylate Mdm2 in vitro and in cultured cells at Ser… CONTINUE READING

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Pim-1 kinase as cancer drug target: An update.

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66–77 Pim-1 Induces the p53 Pathway

D. P. Xirodimas, C. W. Stephen, D. P. Lane
Exp. Cell Res • 2001

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