Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes.

@article{Strekalova2006ElevatedLO,
  title={Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes.},
  author={Helen Strekalova and Carsten Buhmann and Ralf Kleene and Christian Eggers and Jane L. Saffell and John J. Hemperly and Cornelius Weiller and Tomas Mueller-Thomsen and Melitta Schachner},
  journal={Neurobiology of aging},
  year={2006},
  volume={27 1},
  pages={1-9}
}
In this study we surveyed a total of 218 cerebrospinal fluid (CSF) samples from patients with different neurological diseases including Alzheimer disease, non-Alzheimer forms of dementia, other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM, and characterized by immunoblot analysis the molecular forms of L1 and NCAM. We found a significant increase of L1 and a… CONTINUE READING

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In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes .
The proteolytic fragments of L1 , but not NCAM were also elevated in patients with vascular dementia and dementia of mixed type .
The proteolytic fragments of L1 , but not NCAM were also elevated in patients with vascular dementia and dementia of mixed type .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
These observations point to an abnormal processing and/or shedding of L1 and NCAM in dementia - related neurodegeneration and age , respectively , reflecting changes in adhesion molecule - related cell interactions .
Thus , there was an influence of Alzheimer and non - Alzheimer dementias and neurodegeneration on L1 , whereas age and neurodegeneration influenced NCAM concentrations .
Thus , there was an influence of Alzheimer and non - Alzheimer dementias and neurodegeneration on L1 , whereas age and neurodegeneration influenced NCAM concentrations .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
These observations point to an abnormal processing and/or shedding of L1 and NCAM in dementia - related neurodegeneration and age , respectively , reflecting changes in adhesion molecule - related cell interactions .
Thus , there was an influence of Alzheimer and non - Alzheimer dementias and neurodegeneration on L1 , whereas age and neurodegeneration influenced NCAM concentrations .
Thus , there was an influence of Alzheimer and non - Alzheimer dementias and neurodegeneration on L1 , whereas age and neurodegeneration influenced NCAM concentrations .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
These observations point to an abnormal processing and/or shedding of L1 and NCAM in dementia - related neurodegeneration and age , respectively , reflecting changes in adhesion molecule - related cell interactions .
Thus , there was an influence of Alzheimer and non - Alzheimer dementias and neurodegeneration on L1 , whereas age and neurodegeneration influenced NCAM concentrations .
Thus , there was an influence of Alzheimer and non - Alzheimer dementias and neurodegeneration on L1 , whereas age and neurodegeneration influenced NCAM concentrations .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes .
The proteolytic fragments of L1 , but not NCAM were also elevated in patients with vascular dementia and dementia of mixed type .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
In this study we surveyed a total of 218 cerebrospinal fluid ( CSF ) samples from patients with different neurological diseases including Alzheimer disease , non - Alzheimer forms of dementia , other neurodegenerative diseases without dementia and normal controls to quantitate by capture ELISA the concentrations of the immunoglobulin superfamily adhesion molecules L1 and NCAM , and characterized by immunoblot analysis the molecular forms of L1 and NCAM .
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