Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts.

@article{Watson1995ElevatedLO,
  title={Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts.},
  author={Christine J Watson and W. R. Miller},
  journal={British Journal of Cancer},
  year={1995},
  volume={71},
  pages={840 - 844}
}
The transcription factor, milk protein binding factor (MPBF/Stat5), is a member of the STAT family of signalling molecules which mediates prolactin signal transduction in lactating mammary gland by binding to GAS (gamma-interferon activation site) DNA elements. We have determined the levels of STAT factors in nuclear extracts from a variety of human breast tissues including carcinoma and normal 'resting' breast by electrophoretic mobility-shift assay. The results show that the level of STAT… CONTINUE READING
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