Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juveniles.

@article{Bouwman2005ElevatedLO,
  title={Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juveniles.},
  author={Lee Hans Bouwman and Peter Eerligh and Onno T. Terpstra and Mohamed R. Daha and Peter de Knijff and Bart E P B Ballieux and G. Jan Bruining and Arno R. van der Slik and Anja Roos and Bart O Roep},
  journal={Diabetes},
  year={2005},
  volume={54 10},
  pages={3002-6}
}
Mannose-binding lectin (MBL) is a recognition molecule of the lectin pathway of complement and a key component of innate immunity. MBL polymorphisms have been described that are associated with MBL serum concentration, impaired function, and diabetic complications. We investigated 86 new-onset juvenile type 1 diabetic patients and compared these with their nondiabetic siblings and healthy unrelated control subjects. Polymorphisms of MBL exon 1 and promoter were determined, and serum… CONTINUE READING

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