Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia.

@article{Olsson2009ElevatedLO,
  title={Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia.},
  author={Sara K. Olsson and Alexandra S Andersson and Klas R. Linderholm and Maria Holtze and Linda K. Nilsson-Todd and Lilly Schwieler and Elin Olsson and Kerstin Larsson and G{\"o}ran Engberg and S Erhardt},
  journal={The international journal of neuropsychopharmacology},
  year={2009},
  volume={12 4},
  pages={501-12}
}
Kynurenic acid (KYNA) is an endogenous compound implicated in the pathophysiology of schizophrenia. This tryptophan metabolite antagonizes both the N-methyl-D-aspartate (NMDA) receptors and the nicotinic alpha7* receptors at micromolar concentrations. In the present study the effects of amphetamine on dopamine (DA) release in the nucleus accumbens and on firing of DA neurons in the ventral tegmental area (VTA) were investigated in rats treated with kynurenine, the precursor of KYNA, in order to… CONTINUE READING
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