Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia.

Abstract

Kynurenic acid (KYNA) is an endogenous compound implicated in the pathophysiology of schizophrenia. This tryptophan metabolite antagonizes both the N-methyl-D-aspartate (NMDA) receptors and the nicotinic alpha7* receptors at micromolar concentrations. In the present study the effects of amphetamine on dopamine (DA) release in the nucleus accumbens and on… (More)
DOI: 10.1017/S1461145708009383

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@article{Olsson2009ElevatedLO, title={Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia.}, author={Sara K. Olsson and Alexandra S Andersson and Klas R. Linderholm and Maria Holtze and Linda K Nilsson-Todd and Lilly Schwieler and Elin Olsson and Kerstin Larsson and G{\"{o}ran Engberg and S Erhardt}, journal={The international journal of neuropsychopharmacology}, year={2009}, volume={12 4}, pages={501-12} }