Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis

@article{Presslauer2008ElevatedLO,
  title={Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis},
  author={Stefan Presslauer and Dejan Milosavljevic and Thomas Bruecke and Peter Michael Bayer and Wolfgang Huebl},
  journal={Journal of Neurology},
  year={2008},
  volume={255},
  pages={1508-1514}
}
BackgroundNumerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it is now possible to quantitatively measure KFLCs by automated nephelometry. Our objective was to determine the extent to which KFLC levels in CSF correlated with the diagnosis of MS and CISSMS… CONTINUE READING
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