Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension.

@article{Soon2010ElevatedLO,
  title={Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension.},
  author={Elaine Soon and Alan Holmes and Carmen M. Treacy and Natalie J. Doughty and Laura Southgate and Rajiv D Machado and Richard C Trembath and Simon Jennings and Lucy Barker and Paul Nicklin and Christoph Walker and David C. Budd and Joanna W Pepke-Zaba and Nicholas W Morrell},
  journal={Circulation},
  year={2010},
  volume={122 9},
  pages={920-7}
}
BACKGROUND Inflammation is a feature of pulmonary arterial hypertension (PAH), and increased circulating levels of cytokines are reported in patients with PAH. However, to date, no information exists on the significance of elevated cytokines or their potential as biomarkers. We sought to determine the levels of a range of cytokines in PAH and to examine their impact on survival and relationship to hemodynamic indexes. METHODS AND RESULTS We measured levels of serum cytokines (tumor necrosis… CONTINUE READING
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