Elevated levels of chemokine receptor CXCR4 in HER-2 negative breast cancer specimens predict recurrence.

@article{Holm2007ElevatedLO,
  title={Elevated levels of chemokine receptor CXCR4 in HER-2 negative breast cancer specimens predict recurrence.},
  author={Neal T. Holm and Kerry W Byrnes and Benjamin D. L. Li and Richard H. Turnage and Fleurette W. Abreo and J. Michael Mathis and Quyen D. Chu},
  journal={The Journal of surgical research},
  year={2007},
  volume={141 1},
  pages={53-9}
}
INTRODUCTION CXCR4 is a chemokine receptor that has recently been implicated to play a pivotal role in breast cancer growth and metastasis. In animal models, reduction of CXCR4 expression significantly abrogated metastatic disease and prolonged survival. In human breast cancers, CXCR4 overexpression may portend a worse clinical course. Recent data suggest that HER-2 up-regulates CXCR4, but whether this is applicable in the clinical setting is not known. In this study, we evaluated the role of… CONTINUE READING

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