Elevated levels of alpha-synuclein blunt cellular signal transduction downstream of Gq protein-coupled receptors.

Abstract

Alpha-synuclein is central to Parkinson's disease pathogenesis and pathology, however its precise functions are still unclear. It has been shown to bind both PLCβ1 and MAPKs, but how this property influences the downstream signaling of Gq protein-coupled receptors has not been elucidated. Here we show that recombinant expression of alpha-synuclein in human… (More)
DOI: 10.1016/j.cellsig.2016.11.012

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