Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genes.

@article{Giancotti1987ElevatedLO,
  title={Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genes.},
  author={Vincenzo Giancotti and Biljana Pani and Paola D'andrea and Maria Teresa Berlingieri and Pier Paolo Di Fiore and Alfredo Fusco and Giancarlo Vecchio and Roger Philp and Colyn Crane-Robinson and Robert H. Nicolas},
  journal={The EMBO journal},
  year={1987},
  volume={6 7},
  pages={1981-7}
}
Transformation of a rat thyroid epithelial cell line (FRTL5-C12) with Kirsten and Harvey murine sarcoma viruses (carrying the ras oncogenes) results in elevated levels of three perchloric acid-soluble nuclear phosphoproteins. These three proteins are also induced to high levels in the PC-C13 thyroid epithelial cell line when transformed by the myeloproliferative sarcoma virus (carrying the v-mos oncogene) and when transformed by transfection with the c-myc proto-oncogene followed by infection… CONTINUE READING

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