Elevated levels of IgM and IgA antibodies to Proteus mirabilis and IgM antibodies to Escherichia coli are associated with early rheumatoid factor (RF)-positive rheumatoid arthritis.

@article{Newkirk2005ElevatedLO,
  title={Elevated levels of IgM and IgA antibodies to Proteus mirabilis and IgM antibodies to Escherichia coli are associated with early rheumatoid factor (RF)-positive rheumatoid arthritis.},
  author={Marianna M. Newkirk and Raphaela T Goldbach-Mansky and Bernard W. Senior and Jessica Klippel and Harold R. Schumacher and H S El-Gabalawy},
  journal={Rheumatology},
  year={2005},
  volume={44 11},
  pages={1433-41}
}
OBJECTIVE Antibodies to Proteus mirabilis were previously detected in patients with established rheumatoid arthritis (RA). We examined the prevalence of antibodies to P. mirabilis and their associations with RA in early synovitis patients. METHODS Two hundred and forty-six patients with inflammatory arthritis for less than 1 yr were prospectively evaluated for 1 yr. Of these patients, 30% had rheumatoid factor (RF)-positive RA, 16% RF-negative RA, 17% a spondyloarthropathy and 37… CONTINUE READING
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