Elevated levels of Abeta1-40 and Abeta1-42 do not alter the binding sites of nicotinic receptor subtypes in the brain of APPswe and PS1 double transgenic mice.

@article{Marutle2002ElevatedLO,
  title={Elevated levels of Abeta1-40 and Abeta1-42 do not alter the binding sites of nicotinic receptor subtypes in the brain of APPswe and PS1 double transgenic mice.},
  author={Amelia Marutle and Christina Unger and Ewa Hellstr{\"o}m-Lindahl and Jun Wang and Jukka T. Puoliv{\"a}li and Heikki Tanila and A. Nordberg and Xiao Zhang},
  journal={Neuroscience letters},
  year={2002},
  volume={328 3},
  pages={269-72}
}
The binding sites of nicotinic acetylcholine receptor (nAChR) subtypes were measured in the parietal cortex and hippocampus of transgenic mice carrying mutant human APPswe and presenilin 1 (PS1) genes (APPswe/PS1 mice) between the ages of 3 weeks and 17 months. Soluble and insoluble beta-amyloid peptide (Abeta1-40 and Abeta1-42) levels were investigated in parallel. No significant differences in binding sites of [(3)H]cytisine (alpha4beta2 nAChRs) and [(125)I]alpha-bungarotoxin (alpha7 nAChRs… CONTINUE READING

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