Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors.

@article{Liao2004ElevatedLA,
  title={Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors.},
  author={Ching Liao and Sherry Q Li and Xiangyuan Wang and Samantha Muhlrad and Anders Bjartell and Debra J. Wolgemuth},
  journal={International journal of cancer},
  year={2004},
  volume={108 5},
  pages={654-64}
}
Aberrant expression of several key regulators controlling the G1/S phase of the cell cycle has been implicated in human male germ cell tumorigenesis. Given the critical role of cyclin A2 at both the G1/S and G2/M transitions and the essential role for cyclin A1 in male germ cell development, our present study focused on the involvement of the A-type cyclins in the transformation and progression of male germ cell tumors (GCTs). The expression of the A-type cyclins and their catalytic partners… CONTINUE READING

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