Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.

@article{Dziaman2009ElevatedLO,
  title={Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.},
  author={Tomasz Dziaman and Tomasz Huzarski and Daniel Gackowski and Rafal Rozalski and Agnieszka B. Siomek and Anna Szpila and Jolanta Guz and Jan A. Lubiński and Ryszard Olinski},
  journal={International journal of cancer},
  year={2009},
  volume={125 9},
  pages={2209-13}
}
Carriers of BRCA1 mutation face highly increased risk of breast and ovarian cancer and some studies with cell culture suggest that the encoded protein may be involved in oxidatively damaged DNA repair. However, no studies concerning a possible link between oxidatively damaged DNA and BRCA1 deficiency have been conducted with the mutations carriers. Therefore, to assess an involvement of BRCA in oxidative damage to DNA in the present study a broad spectrum of parameters reflecting oxidative… CONTINUE READING

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