Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair

Abstract

Apurinic/apyrimidinic (AP) sites are frequently generated in the genome by spontaneous depurination/depyrimidination or after removal of oxidized/modified bases by DNA glycosylases during the base excision repair (BER) pathway. Unrepaired AP sites are mutagenic and block DNA replication and transcription. The primary enzyme to repair AP sites in mammalian… (More)
DOI: 10.18632/oncotarget.12113

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