Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: Interplay between hematologic and solid neoplastic clones and their microenvironments.

Abstract

Metabolism of neoplastic cells is shifted toward high glucose uptake and enhanced lactate production. Lactate dehydrogenase (LDH), which is comprised of two major subunits, LDH-A and LDH-B, reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate. LDH-A has a higher affinity for pyruvate and is a key enzyme in the glycolytic pathway… (More)
DOI: 10.3233/CBM-160336

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Cite this paper

@article{Ding2017ElevatedLD, title={Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: Interplay between hematologic and solid neoplastic clones and their microenvironments.}, author={Jennifer Ding and Judith E. Karp and Ashkan Emadi}, journal={Cancer biomarkers : section A of Disease markers}, year={2017}, volume={19 4}, pages={353-363} }