Elevated labile Cu is associated with oxidative pathology in Alzheimer disease.

  title={Elevated labile Cu is associated with oxidative pathology in Alzheimer disease.},
  author={S A James and Irene Volitakis and Paul A. Adlard and James A Duce and Colin L. Masters and Robert Alan Cherny and Ashley I. Bush},
  journal={Free radical biology & medicine},
  volume={52 2},
Oxidative stress is implicated in Alzheimer disease (AD) pathogenesis, for which evidence indicates that radical species are generated by the redox-active biometal Cu. The contribution of labile Cu to the oxidative stress observed in AD has not been evaluated. The Cu content of postmortem cortical tissue from nondemented elderly controls and AD cases was measured using inductively coupled plasma mass spectroscopy, and the proportion of labile Cu was assessed using the Cu-phenanthroline assay… CONTINUE READING
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