Elevated interleukin-18 protein expression in early active and progressive plaque-type psoriatic lesions.

@article{Companjen2004ElevatedIP,
  title={Elevated interleukin-18 protein expression in early active and progressive plaque-type psoriatic lesions.},
  author={Arjen R. Companjen and Leontine I van der Wel and Leslie van der Fits and Jon D Laman and E P Prens},
  journal={European cytokine network},
  year={2004},
  volume={15 3},
  pages={210-6}
}
Psoriasis is a T cell-mediated inflammatory skin disease characterized by an elevated IFN-gamma and IL-12p70 expression in skin lesions. Interleukin-18 (IL-18) synergizes with IL-12 to induce IFN-gamma production and a strong T-helper-1-mediated immune response, or to induce Th2 polarization depending on the immunological context. We have previously shown that keratinocytes in normal skin produce and store large amounts of pro-IL-18. In this study, we hypothesized that the expression of IL-18… CONTINUE READING