Elevated insular glutamate in fibromyalgia is associated with experimental pain.

@article{Harris2009ElevatedIG,
  title={Elevated insular glutamate in fibromyalgia is associated with experimental pain.},
  author={Richard E. Harris and Pia C. Sundgren and Arthur D Bud Craig and Eric Kirshenbaum and Ananda Sen and Vitaly Napadow and Daniel J. Clauw},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 10},
  pages={3146-52}
}
OBJECTIVE Central pain augmentation resulting from enhanced excitatory and/or decreased inhibitory neurotransmission is a proposed mechanism underlying the pathophysiology of functional pain syndromes such as fibromyalgia (FM). Multiple functional magnetic resonance imaging studies implicate the insula as a region of heightened neuronal activity in this condition. Since glutamate (Glu) is a major cortical excitatory neurotransmitter that functions in pain neurotransmission, we undertook this… CONTINUE READING
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