Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells

@article{Ju2009ElevatedHP,
  title={Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells},
  author={Won-Kyu Ju and Keun-Young Kim and James Lindsey and Mila Angert and Ankur Patel and Ray T Scott and Quan Liu and Jonathan G. Crowston and Mark H. Ellisman and Guy A Perkins and Robert N. Weinreb},
  journal={Molecular Vision},
  year={2009},
  volume={15},
  pages={120 - 134}
}
PURPOSE This study was conducted to determine whether elevated hydrostatic pressure alters mitochondrial structure, triggers release of the dynamin-related guanosine triphosphatase (GTPase) optic atrophy type 1 (OPA1) or cytochrome C from mitochondria, alters OPA1 gene expression, and can directly induce apoptotic cell death in cultured retinal ganglion cell (RGC)-5 cells. METHODS Differentiated RGC-5 cells were exposed to 30 mmHg for three days in a pressurized incubator. As a control… CONTINUE READING

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