Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells.

@article{ZoltanJones2003ElevatedHP,
  title={Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells.},
  author={Alexandra Zoltan-Jones and Lei Huang and Shilenath Ghatak and Bryan P. Toole},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 46},
  pages={45801-10}
}
During carcinoma progression, tumor cells often undergo changes similar (but not identical) to epithelialmesenchymal transitions in embryonic development. In this study, we demonstrate that experimental stimulation of hyaluronan synthesis in normal epithelial cells is sufficient to induce mesenchymal and transformed characteristics. Using recombinant adenoviral expression of hyaluronan synthase-2, we show that increased hyaluronan production promotes anchorage-independent growth and… CONTINUE READING
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