Elevated hsa-miR-99a levels in maternal plasma may indicate congenital heart defects.

  title={Elevated hsa-miR-99a levels in maternal plasma may indicate congenital heart defects.},
  author={Lars Kehler and Orsolya B{\'i}r{\'o} and Levente L{\'a}z{\'a}r and J{\'a}nos Rig{\'o} and B{\'a}lint Nagy},
  journal={Biomedical reports},
  volume={3 6},
The current standard for prenatal screening is mostly based on biochemical marker tests and the use of ultrasonography. There is no secure stand-alone screening marker for congenital heart defects (CHDs). MicroRNAs (miRNAs) that are associated with cardiogenesis enter the maternal peripheral bloodstream during pregnancy and allow non-invasive prenatal testing (NIPT). The present study investigated the plasma expression profile of fetal hsa-miR-99a in maternal blood. Peripheral blood samples… CONTINUE READING


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